Nairne is a surname and may be:
Clayton Nairne (1904-1989), President of New Orleans Public Service, 1964 King of Carnival, New Orleans, LA; Winner of the 1972 Loving Cup
Alexander Robert Sandy Nairne (born 1953), a British art museum director
Andrew Nairne, British executive director for Arts Strategy at Arts Council England
Carolina, Baroness Nairne (1766–1845), a Scottish songwriter and song collector
General Sir Charles Edward Nairne KCB (1836–1899), Commander-in-Chief in India
Edward Nairne (1726–1806), an English optician and scientific instrument maker
Lieutenant-Colonel John Nairne (1731–1802), a Scottish-Canadian soldier and seigneur
Sir John Gordon Nairne (1861–1945), British director of the Bank of England and a BBC governor
Sir Patrick Nairne (1921–2013), a senior British civil servant
Rob Nairne (born 1954), a former American football linebacker
Thomas Nairne (died 1715), a Scottish trader
William Murray Nairne (1657–1730), 2nd Baron Nairne