Nagle is a surname. Notable people with the surname include:
Browning Nagle (born 1968), American football quarterback
Courtney Nagle (born 1982) American tennis player
David R. Nagle (born 1943), Representative in the United States House of Representatives
Don Nagle, American karate Grand Master
Florence Nagle. British feminist, racehorse trainer and dog breeder.
Jack Nagle (1917-1991), head coach of the Marquette University men’s basketball team
Jacob Nagle (1761-1841), Royal Navy sailor
John Nagle, author of RFC896, see: Nagle's algorithm
Kel Nagle (1920–2015), Australian golfer
Mackey Nagle, a recurring character on Smart Guy
Margaret Nagle (born 1969), screenwriter and TV producer
Matt Nagle (circa 1979-2007), one of the first people to use a brain-computer interface to restore functionality lost due to paralysis
Nano Nagle (1718-1784), founder of the Presentation Sisters
Noel Nagle (21st century), Irish musician
Ron Nagle (born 1939), American ceramic sculptor
William Nagle (author) (1947-2002), Australian soldier and author
William Nagle (football coach) (19th century), former head coach of the Boston College college football program