Nagle is a surname. Notable people with the surname include:
Browning Nagle (born 1968), American football quarterbackCourtney Nagle (born 1982) American tennis playerDavid R. Nagle (born 1943), Representative in the United States House of RepresentativesDon Nagle, American karate Grand MasterFlorence Nagle. British feminist, racehorse trainer and dog breeder.Jack Nagle (1917-1991), head coach of the Marquette University men’s basketball teamJacob Nagle (1761-1841), Royal Navy sailorJohn Nagle, author of RFC896, see: Nagle's algorithmKel Nagle (1920–2015), Australian golferMackey Nagle, a recurring character on Smart GuyMargaret Nagle (born 1969), screenwriter and TV producerMatt Nagle (circa 1979-2007), one of the first people to use a brain-computer interface to restore functionality lost due to paralysisNano Nagle (1718-1784), founder of the Presentation SistersNoel Nagle (21st century), Irish musicianRon Nagle (born 1939), American ceramic sculptorWilliam Nagle (author) (1947-2002), Australian soldier and authorWilliam Nagle (football coach) (19th century), former head coach of the Boston College college football program