Species Human Entrez 55655 | Human Mouse Ensembl n/a | |
Aliases NLRP2, CLR19.9, NALP2, NBS1, PAN1, PYPAF2, NLR family, pyrin domain containing 2, NLR family pyrin domain containing 2 External IDs MGI: 3041206 HomoloGene: 56789 GeneCards: NLRP2 | ||
NACHT, LRR and PYD domains-containing protein 2 is a protein that in humans is encoded by the NLRP2 gene.
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003).[supplied by OMIM]
References
NLRP2 Wikipedia(Text) CC BY-SA