Entrez 4799 | Ensembl ENSG00000086102 | |
Aliases NFX1, NFX2, TEG-42, Tex42, nuclear transcription factor, X-box binding 1 External IDs MGI: 1921414 HomoloGene: 1875 GeneCards: NFX1 |
Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-γ. Three alternative splice variants, each of which encodes a different isoform, have been identified.
References
NFX1 Wikipedia(Text) CC BY-SA