Entrez 4745 | Ensembl ENSG00000165973 | |
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Aliases NELL1, IDH3GL, NRP1, neural EGFL like 1 External IDs MGI: 2443902 HomoloGene: 4486 GeneCards: NELL1 | ||
Protein kinase C-binding protein NELL1 also known as NEL-like protein 1 (NELL1) or Nel-related protein 1 (NRP1) is a protein that in humans is encoded by the NELL1 gene.
Function
This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full-length sequence has not been determined.
Recent study by UCLA researchers shows that administering the protein NELL-1 intravenously stimulates significant bone formation through the regenerative ability of stem cells.
References
NELL1 Wikipedia(Text) CC BY-SA