Entrez 4835 | Ensembl ENSG00000124588 | |
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Aliases NQO2, Nqo2, NMO2, Nmor2, Ox2, DHQV, DIA6, QR2, NAD(P)H quinone dehydrogenase 2 External IDs MGI: 104513 HomoloGene: 696 GeneCards: NQO2 | ||
NAD(P)H dehydrogenase, quinone 2, also known as NQO2 or QR2, is a human gene. It is a phase II detoxification enzyme which can carry out two or four electron reductions. Its mechanism of reduction is via a covalently bound zinc ion and a cocrystalized FAD. NQO2 contains two chains homologous in AA sequence but 7% different in structure. As a result, NQO2 contains two similar yet unique active sites. An important function of NQO2 is its activation on NRH. NQO2 can be inhibited by resveratrol.
References
NAD(P)H dehydrogenase, quinone 2 Wikipedia(Text) CC BY-SA