Neha Patil (Editor)

N2 (2 carboxyethyl)arginine synthase

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
EC number
  
2.5.1.66

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

MetaCyc
  
metabolic pathway

In enzymology, a N2-(2-carboxyethyl)arginine synthase (EC 2.5.1.66) is an enzyme that catalyzes the chemical reaction

D-glyceraldehyde 3-phosphate + L-arginine N2-(2-carboxyethyl)-L-arginine + phosphate

Thus, the two substrates of this enzyme are D-glyceraldehyde 3-phosphate and L-arginine, whereas its two products are N2-(2-carboxyethyl)-L-arginine and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming). Other names in common use include CEAS, N2-(2-carboxyethyl)arginine synthetase, CEA synthetase, glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl), and transferase (2-carboxyethyl-forming). This enzyme participates in clavulanic acid biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2IHT and 2IHV.

References

N2-(2-carboxyethyl)arginine synthase Wikipedia