N1 acetylpolyamine oxidase

Updated on Dec 23, 2024

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EC number 1.5.3.13 BRENDA BRENDA entry KEGG KEGG entry		IntEnz IntEnz view ExPASy NiceZyme view MetaCyc metabolic pathway

N¹-acetylpolyamine oxidase (EC 1.5.3.13, hPAO-1, mPAO, hPAO) is an enzyme with systematic name N¹-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming). This enzyme catalyses the following chemical reaction

(1) N¹-acetylspermidine + O₂ + H₂O ⇌ putrescine + 3-acetamidopropanal + H₂O₂(2) N¹-acetylspermine + O₂ + H₂O ⇌ spermidine + 3-acetamidopropanal + H₂O₂

This enzyme also catalyses the reaction:

N¹,N¹²-diacetylspermine + O₂ + H₂O ⇌ N₁-acetylspermidine + 3-acetamamidopropanal + H₂O₂.

References

N1-acetylpolyamine oxidase Wikipedia

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