Myristoyl CoA 11 (Z) desaturase

In enzymology, a myristoyl-CoA 11-(Z) desaturase (EC 1.14.99.32) is an enzyme that catalyzes the chemical reaction

myristoyl-CoA + NAD(P)H + H⁺ + O₂ ⇌ (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H₂O

The 5 substrates of this enzyme are myristoyl-CoA, NADH, NADPH, H⁺, and O₂, whereas its 4 products are (Z)-11-tetradecenoyl-CoA, NAD⁺, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(Z) desaturating]. This enzyme is also called n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(Z) desaturating].