Formula C21H39NO6 | Molar mass 401.54 g/mol | |
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How to pronounce myriocin
Myriocin, also known as antibiotic ISP-1 and thermozymocidin, is an atypical amino acid and an antibiotic derived from certain thermophilic fungi. Among the producing strains are Mycelia sterilia.
Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids.
Myriocin was shown to inhibit the proliferation of an IL-2-dependent mouse cytotoxic T cell line.
Myriocin possesses immunosuppressant activity. It is reported to be 10- to 100-fold more potent than ciclosporin.
The multiple sclerosis drug fingolimod was derived from myriocin by using structure–activity relationship studies to determine the parts of the molecule important to its activity.