Muzio is a surname. Notable people with the surname include:
Christine Muzio (born 1951), French fencerClaudia Muzio (1889–1936), Italian operatic sopranoEmanuele Muzio (1821–1890), Italian composer, conductor and vocal teacherGiovanni Muzio (1893-1982), Italian architectGirolamo Muzio (1496–1576), Italian courtier, poet, and author in defence of the vernacular Italian language against LatinGloria Muzio, American theatre and television director