Mullane is a surname. Notable people with the surname include:
Christopher Mullane (ONZM, MBE, Legion of Merit (USA)), Retired Lieutenant Colonel of the New Zealand ArmyDan Mullane, Irish celebrity chef, television personality, proprietor of The Mustard Seed in Ballingarry, County LimerickDavid Mullane, 1990s rugby league footballerGreg Mullane, Australian rugby league footballerJackson Mullane (born 1987), Australian film director, screenwriter and actorJohn Mullane (born 1981), Irish hurler who played as a right corner-forward for the Waterford senior teamJye Mullane (born 1981), Australian rugby league playerMike Mullane (born 1945), retired USAF officer and a former NASA astronautPatrick Mullane VC (1858–1919), recipient of the Victoria CrossTony Mullane (1859–1944), Irish Major League Baseball player