Mukasa is a surname. Notable people with the surname include:
Adolphus Ludigo-Mukasa (1861–1886), Ugandan Roman Catholic martyred for his faithMukasa Mbidde (born 1973), Ugandan lawyer, human-rights activist, politicianAshe Mukasa (born 1952), former Ugandan football midfielderBasammula-Ekkere Mwanga II Mukasa (1868–1903), Kabaka of Buganda from 1884 until 1888 and from 1889 until 1897Ham Mukasa (1868–1956), page in the court of Mutesa I of Buganda and later secretary to Apolo KagwaJoseph Mukasa Balikuddembe (1860–1885), Ugandan Roman Catholic recognized as a martyr and saint by the Catholic ChurchRoger Mukasa, (born 1989), Ugandan cricketerRuben Spartas Mukasa (1899–1982), religious reformer in UgandaWilson Muruli Mukasa, Ugandan politicianJoseph Mukasa Zuza (1955–2015), Roman Catholic bishop