Most is a surname. Some notable people with the surname include:
Deforrest Most (1917-2006), American gymnastDon Most (born 1953), American actorDoug Most (born 1968), editor of The Boston Globe MagazineGlenn W. Most (born 1952), American classicist and comparatistJeff Most (born 1960), American film producerJohann Most (1846–1906), German-American anarchist and oratorJohnny Most (1923–1993), American sports announcerMickie Most (1938–2003), English record producerSam Most (born 1930), Los Angeles-based jazz flautist and tenor saxophonist