Moorehouse is a surname. Notable people with the surname include:
Alan Moorehouse Charlesworth (1904–1978), a senior commander in the Royal Australian Air ForceFrancis Moorehouse (died 1982), an American labor relations specialistMatilda Moorehouse Barratt (1837–1902), a prominent member of The Church of Jesus Christ of Latter-day SaintsRuth Ann "Ouisch" Moorehouse, a follower of Charles MansonTrevor Moorehouse, a character in the 2000 teen slasher film Bloody Murder