Montefiore is a surname associated with the Montefiore family, Sephardi Jews who were diplomats and bankers all over Europe and who originated from Morocco and Italy. Notable people with the surname include:
Claude Montefiore (1858–1938), Jewish philosopher
Dora Montefiore
Fausto Montefiore
Hugh Sebag-Montefiore (born 1955), author, attorney, and journalist
Hugh Montefiore (1920–2005), bishop of Birmingham, 1977–1987, and environmentalist (born Hugh Sebag-Montefiore)
Moses Montefiore (1784–1885), prominent British Jew, financier, stockbroker, banker and philanthropist
John Israel Montefiore (1807–1898), New Zealand trader and merchant
Georges Montefiore-Levi (1832–1906), Belgian inventor and philanthropist
Santa Montefiore (born 1970), author
Simon Sebag Montefiore (born 1965), author