Monoterpene epsilon lactone hydrolase

Monoterpene epsilon-lactone hydrolase (EC 3.1.1.83, MLH) is an enzyme with systematic name isoprop(en)ylmethyloxepan-2-one lactonohydrolase. This enzyme catalyses the following chemical reaction

(1) isoprop(en)ylmethyloxepan-2-one + H₂O ⇌ 6-hydroxyisoprop(en)ylmethylhexanoate (general reaction) (2) 4-isopropenyl-7-methyloxepan-2-one + H₂O ⇌ 6-hydroxy-3-isopropenylheptanoate (3) 7-isopropyl-4-methyloxepan-2-one + H₂O ⇌ 6-hydroxy-3,7-dimethyloctanoate

The enzyme catalyses the ring opening of epsilon-lactones in Gram-positive bacterium Rhodococcus erythropolis DCL14.