"Mona Lisa Overdrive" is a song, featured in the movie The Matrix Reloaded, during the well-known highway chase scene. It is composed by Don Davis in collaboration with the electronica act Juno Reactor, representing blend of film score music and trance. The track is the fifth entry in the second CD in the film soundtrack, released on 15 May 2003. An edited (shortened from its original time of 10:08 to 4:45) and slightly different version of the song is featured in Juno Reactor's sixth album Labyrinth in 2004." A remix of the song was produced by Thomas P. Heckmann and included in group's remix album Inside The Reactor in 2011.
The song title is derived from William Gibson's cyberpunk novel of the same name, published in 1988. The Matrix Trilogy was heavily influenced by Gibson's writing.