Mole is a surname. Notable people with the surname include:
Charles Mole (1886–1962), British architect
Chris Mole (born 1958), UK Labour Member of Parliament
Fenton Mole (born 1925), American baseball player
Jamie Mole (born 1988), English professional footballer
Miff Mole, (1898–1961), American jazz trombonist and band leader
Fictional characters:
Adrian Mole, fictional diarist in a series of comic novels by Sue Townsend
Rosie Mole, Adrian's sister