Modified Maddrey's discriminant function

The modified Maddrey's discriminant function) was originally described by Maddrey and Boitnott to predict prognosis in alcoholic hepatitis. It is calculated by a simple formula:

(4.6 x (PT test - control))+ S.Bilirubin in mg/dl

Prospective studies have shown that it is useful in predicting short term prognosis especially mortality within 30 days. A value more than 32 implies poor outcome with one month mortality ranging between 35% to 45%. Corticosteroid therapy or pentoxifylline have been used with mixed results for patients whose increased mortality is indicated with a value greater than 32.

To calculate Maddrey discriminant function using SI units - micromol/l (i.e. not US) divide bilirubin value by 17.