Mizuno is a Japanese surname. Notable people with the surname include:
Awa Mizuno (born 1968), pen name of Japanese manga artist, Ken Akamatsu
Haruki Mizuno (born 1979), Japanese AV Idol
Hideko Mizuno (born 1939), Japanese artist and manga artist
Hiroko Mizuno (born 1974), Japanese professional wrestling personality
Junko Mizuno (born 1973), Japanese artist and manga artist
Katsuhiro Mizuno, Japanese pop star
Koki Mizuno (born 1985), Japanese footballer
Maki Mizuno (born 1970), Japanese actress
Miki Mizuno (born 1974), Japanese actress
Mizuno Nobumoto (died 1576), Japanese feudal lord
Ryo Mizuno (born 1963), Japanese author and game designer
Mizuno Tadashige (1541–1600), figure in Japanese history
Mizuno Tadakuni (1794–1851), Japanese official
Yoshikane Mizuno, a Japanese astronomer
Mizuno Rentarō (1868–1949), Japanese politician and cabinet minister
Mizuno Tadanori
Yui Mizuno (born 1999), Japanese Idol, model, and singer from Kawaii Metal band Babymetal
Fictional characters:
Ami Mizuno (also known as "Amy Mizuno" or "Amy Anderson") in Sailor Moon
Haruka Mizuno, a character in Tokyo Daigaku Monogatari
Sunabozu (Kanta Mizuno), from the anime series, Desert Punk
Katsuo Mizuno, from the manga/anime series The Prince of Tennis
Suzy Mizuno (Suzume Mizuno) in Zatch Bell! (Konjiki no Gash Bell!!)
Tomomi Mizuno, from the eroge (erotic video game), Dōkyūsei 2
Azusagawa Mizuno, from the anime and manga series Yakitate!! Japan