Samiksha Jaiswal (Editor)

Mitogen activated protein kinase kinase

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EC number
  
2.7.12.2

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

MetaCyc
  
metabolic pathway

Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK).

MAP2K is classified as EC 2.7.12.2.

There are seven genes:

  • MAP2K1 (a.k.a. MEK1)
  • MAP2K2 (a.k.a. MEK2)
  • MAP2K3 (a.k.a. MKK3)
  • MAP2K4 (a.k.a. MKK4)
  • MAP2K5 (a.k.a. MKK5)
  • MAP2K6 (a.k.a. MKK6)
  • MAP2K7 (a.k.a. MKK7)

    • The activators of p38 (MKK3 and MKK6), JNK (MKK4 and MKK7), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways. The acronym MEK derives from MAPK/ERK Kinase.

    Role in melanoma

    MEK is a member of the MAPK signaling cascade that is activated in melanoma. When MEK is inhibited, cell proliferation is blocked and apoptosis (controlled cell death) is induced.

    References

    Mitogen-activated protein kinase kinase Wikipedia
    (Text) CC BY-SA