Mir 605 microRNA precursor family

p53 protein network

miR-605 is transcriptionally activated by the p53 protein through interaction with the promoter region of its gene. This microRNA in turn post-transcriptionally represses the oncoprotein and p53 suppressor Mdm2, which acts with p53 in a negative feedback loop in p53-wildtype cancers. Introduction of miR-605 interrupts this p53:Mdm2 interaction and instead there is a positive feedback loop in place, enabling rapid p53 accumulation in response to stress. Such p53 accumulation induces cell cycle arrest and apoptosis.