Symbol mir-601 miRBase family MIPF0000522 Domain(s) Eukaryota; | Rfam RF01006 RNA type microRNA | |
In molecular biology mir-601 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Molecular pathway regulation
miR-601 has been found to affect a number of different cell signalling pathways, more specifically bringing about downregulation of Fas-induced apoptosis and NF-kappa B signalling. There is additionally upregulation of the actin cytoskeleton and increased negative regulation of translational initiation by miR-601. The importance of NF-kappa B in tumour cell proliferation and enhanced survival means that miR-601 mimics may hold a lot of promise for prevention or treatment of carcinogenesis.
miR-602 has further been linked to the development and progression of gastric cancer, with levels significantly upregulated compared with normal gastric tissue.