Symbol mir-221 miRBase family MIPF0000051 OMIM 300568 | Rfam RF00651 HUGO 31601 RNA type microRNA | |
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In molecular biology mir-221 microRNA (and its paralogue, mir-222) is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
mir-221 is an oncogenic microRNA. It targets CD117, which then prevents cell migration and proliferation in endothelial cells. miR-221 is known as an anti angiogenic miRNA. Recent important studies have reported that miR-221 is also involved in induction of angiogenesis. RNA induced Silencing Complex (RISC) proteins SND1 and AEG-1 induces miR-221 expression in Liver cancer. In liver cancer miR-221 induces the tumor angiogenesis. miR-221 detection in human faeces can be a non-invasive screening marker for colorectal cancer.
References
Mir-221 microRNA Wikipedia(Text) CC BY-SA