Mikołaj II Radziwiłł (Lithuanian: Mikalojus Radvila) (1470–1521) was a magnate and statesman of the Grand Duchy of Lithuania.
He obtained the title of prince from Emperor Maximilian I. He was a son of Mikalojus Radvilaitis and among the first Radziwiłłs to cary this family name. He had brothers Jerzy Radziwiłł, Jan Radziwiłł and Wojciech Radziwiłł and sister Anna Radziwiłł. Mikołaj was a progenitor of Goniądz–Meteliai Radziwiłł family line. He inherited the lands of Musninkai and Kėdainiai. Most of his acquired fortune had been confiscated from Michael Glinski—notably Raigardas, Goniądz and Knyszyn.
He took part in the second Muscovite–Lithuanian War of 1500–03 and other raids under leadership of Konstanty Ostrogski. Mikołaj was the Podczaszy from 1505 until 1510, Voivode of Vilnius from 1507 and replaced his father as the Grand Chancellor of Lithuania from 1510.
Due to his pro-Polish views and arid support for the Polish–Lithuanian Union he was ironically nicknamed Amor Poloniae by his contemporaries. He rivaled Albertas Goštautas for influence in the government of the Grand Duchy of Lithuania and was the initial editor of the First Statute of Lithuania.