Mikhaylov or Mikhaylova, also transliterated as Mikhailov, is a surname. Notable people with the surname include:
Adrian Mikhaylov (1853–1929), Russian revolutionary
Alexander Mikhaylov (disambiguation), several people
Boris Mikhailov (ice hockey), Soviet ice hockey player
Boris Mikhailov (photographer) (1938-?), Ukrainian photographer
Boris Mikhaylovich Mikhaylov (1906-?), Soviet chemist
Borislav Mikhailov (born 1962), former Bulgaria international footballer
Ivan Mihailov (1896–1990), Bulgarian revolutionary
Khristo Mikhailov (1893–1944), Bulgarian politician
Konstantin Mikhailov-Stoyan (1853–1914), Bulgarian opera singer and actor
Lev Mikhailov (1872–1928), Russian revolutionary
Maxim Mikhailov (1893–1971), Russian opera singer
Maxim Mikhaylov (born 1988), Russian volleyball player
Mikhail Mikhaylov (disambiguation), several people
Nikolay Ivanovich Mikhaylov (1915-?), Soviet geographer
Nikolay Mihaylov (born 1988), Bulgarian footballer and son of Borislav Mikhailov
Nikolay Mikhaylov (1906-?), Russian proletarian writer
Nikolay Nikolayevich Mikhaylov (1905–1998), Soviet writer
P. Mikhailov, Russian soloist with the Alexandrov Ensemble
Sergey Mikhaylov (disambiguation), several people
Spiridon Mikhaylov (1821–1861), Russian historian, folklorist, and writer
Tanja Mihhailova (born 1983), Estonian singer
Timofey Mikhaylov (1859–1881), Russian revolutionary, member of Narodnaya Volya
Viktor Mikhaylov (1934–2011), Russian academic and nuclear scientist
Vladimir Mikhaylov (disambiguation), multiple people
Yegor Mikhailov (born 1978), Russian ice hockey player
Yuri Mikhaylov (born 1930), Soviet speed skater
