Mighty Mouse is a nickname for:
Eric Aiken (born 1980), American featherweight boxer and former IBF world champion
Jimmy Alapag (born 1977), Philippine Basketball Association player
Pam Barrett (1953–2008), Canadian politician
Chuck Fenenbock (1917–1998), American National Football League and Canadian Football League player
Shannon Gallant (born 1986), Australian rugby league player
Demetrious Johnson (fighter) (born 1986), American mixed martial arts fighter and UFC Flyweight champion
Kevin Keegan, English former footballer
Tony Leswick (1923–2001), Canadian National Hockey League player
Ian McLauchlan (born 1942), Scottish retired rugby union player
Mark McMillian (born 1970), American retired National Football League player
Kyla Ross (born 1996), American artistic gymnast
Michael Russell (tennis) (born 1978), American tennis player
Damon Stoudamire (born 1973), American retired National Basketball Association player
Elaine Tanner (born 1951), Canadian retired swimmer
Zhang Anda (born 1991), Chinese snooker player