The Middletown Rancheria of Pomo Indians of California is a federally recognized tribe of Pomo Indians, as well as some Wappo and Lake Miwok Indians, in California, headquartered in Middletown, California.
The tribe's reservation is the Middletown Rancheria, located north-northeast of Santa Rosa. It was established in 1910 and occupies 109 acres (0.44 km2) in Lake County. Approximately 73 tribal members live on the reservation.
The Middletown Pomos own the Twin Pine Casino and Hotel, located in Middletown.