External IDs GeneCards: MIR196A2 Human Mouse Ensembl ENSG00000207924 | Species Human Entrez 406973 | |
Aliases MIR196A2, MIRN196-2, MIRN196A2, mir-196a-2, Microrna 196a-2 | ||
MicroRNA 196a-2 is a MicroRNA that in humans is encoded by the MIR196A2 gene, and is part of the Mir-196 microRNA precursor family.
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.