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Trade names  Posicor
Routes of administration  By mouth (tablets)
Legal status  Withdrawn from market
Bioavailability  70%
MedlinePlus  a607007
ATC code  C08CX01 (WHO)
Molar mass  495.63 g/mol
AHFS/  Micromedex Detailed Consumer Information

Mibefradil (Posicor) is a drug for the treatment of hypertension and chronic angina pectoris. It belongs to a group known as calcium channel blockers.

The mechanism of action of mibefradil is characterized by the selective blockade of transient, low-voltage-activated (T-type) calcium channels over long-lasting, high-voltage-activated (L-type) calcium channels, which is probably responsible for many of its unique properties.

It is nonselective.

On June 8, 1998, Roche announced the voluntary withdrawal of the drug from the market, one year after approval by the FDA, due to the potential for drug interactions, some of them deadly, which may occur when it is taken together with some other medications.


Mibefradil Wikipedia

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