Symbol Mga Pfam clan CL0123 Pfam structures | Pfam PF05043 InterPro IPR007737 PDB RCSB PDB; PDBe; PDBj | |
Mga is a DNA-binding protein that activates the expression of several important virulence genes in Streptococcus pyogenes (group A Streptococcus, GAS) in response to changing environmental conditions. The family also contains VirR like proteins which match only at the C-terminus.
Mga is a wide-reaching regulator, affecting gene expression in over 10% of the S. pyrogenes genome. The other large regulator of virulence in GAS is the CovR/S two-component system, which affects the expression of approximately 15% of the genome. The two systems are linked through another protein, RivR, and a small non-coding RNA RivX.
References
Mga (protein) Wikipedia(Text) CC BY-SA