Trade names Myalept Legal status US: ℞-only DrugBank DB09046 Molar mass 16,156 g/mol | ATC code A16AA07 (WHO) CAS Number 186018-45-1 Formula C714H1167N191O221S6 | |
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Synonyms Mettreleptin; N-Methionylleptin; r-metHuLeptin | ||
Metreleptin for generalized lipodystrophy video abstract 66521
Metreleptin (trade name Myalept) is a synthetic analog of the hormone leptin used to treat diabetes and various forms of dyslipidemia. It is has been approved in Japan for metabolic disorders including lipodystrophy and in the United States as replacement therapy to treat the complications of leptin deficiency, in addition to diet, in patients with congenital generalized or acquired generalized lipodystrophy.
Metreleptin is currently being investigated for the treatment of diabetes and/or hypertriglyceridemia, in patients with rare forms of lipodystrophy, syndromes characterized by abnormalities in adipose tissue distribution, and severe metabolic abnormalities.
In a three-year study of metreleptin in patients with lipodystrophy organized by the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health, metreleptin treatment was associated with a significant decrease in blood glucose (A1c decreased from 9.4% at baseline to 7.0% at study end) and triglyceride concentration (from 500 mg/dl at baseline to 200 mg/dl at study end).