Formula C10H10N4OS | Molar mass 234.28 g/mol | |
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Methisazone (USAN) or metisazone (INN) is an antiviral drug that works by inhibiting mRNA and protein synthesis, especially in pox viruses. It has been used in the past to treat smallpox.
Methisazone has been described as being used in prophylaxis since at least 1965.
Synthesis
When isatin is treated with NaH and MeI, the acidic hydrogen is alkylated to product 2. Then, reaction of the ketone carbonyl with thiosemicarbazine (3) leads to methisazone (4).
References
Metisazone Wikipedia(Text) CC BY-SA