Methylated thiol coenzyme M methyltransferase

Methylated-thiol-coenzyme M methyltransferase (EC 2.1.1.251, mtsA (gene)) is an enzyme with systematic name methylated-thiol:coenzyme M methyltransferase. This enzyme catalyses the following chemical reaction

methanethiol + coenzyme M ⇌ methyl-CoM + hydrogen sulfide (overall reaction)(1a) methanethiol + [Co(I) methylated-thiol-specific corrinoid protein] ⇌ [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide(1b) [methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M ⇌ methyl-CoM + [Co(I) methylated-thiol-specific corrinoid protein]

This enzyme involved in methanogenesis from methylated thiols, such as methanethiol, dimethyl sulfide, and 3-S-methylmercaptopropionate.