Symbol Methuselah_N InterPro IPR010596 SUPERFAMILY 1fjr | Pfam PF06652 SCOP 1fjr Pfam structures | |
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The Methuselah-like proteins are a family of G protein-coupled receptors found in insects that play a role in aging and reproduction. Antagonizing these receptors can extend the life span of the animal and make it more resistant to free radicals and starvation, but also reduce reproduction and increase cold sensitivity. The age dependent decline in olfaction and motor function is unaffected.
Methuselah-like proteins are related to G protein-coupled receptors of the secretin receptor family.
References
Methuselah-like proteins Wikipedia(Text) CC BY-SA