Messina is a surname. Notable people with the surname include:
Messina brothers
Antonello da Messina, Sicilian renaissance painter
Chris Messina, actor
Chris Messina (open source advocate)
Daniele Messina, (born 1992) Italian footballer
David Messina, Italian comics artist
Ettore Messina, basketball coach
Giuseppe Messina, Italian footballer
Guido Messina, Italian road bicycle and track cyclist
Jim Messina (political staffer) (born 1969), American political adviser
Jim Messina (musician), rock artist
Jo Dee Messina, singer-songwriter
