Messer is both a surname and a given name. Notable people with the name include:
Surname:
Casey Messer (born 1983), beauty queen
Chris Messer (21st century), United States singer
Dale Messer American footballer
Danny Messer, television series character from CSI: NY
David Messer (21st century), Australian cartoonist
Don Messer (1909–1973), Canadian musician
Donald E. Messer (born 1941), American United Methodist theologian and author
Erica Messer (21st century), American television writer, producer and story editor
Frank Messer (1925–2001), American sportscaster
Glenn Edmund Messer (1895–1995), aviation pioneer
Jonathan Messer (born 1973), Australian director
Leon Messer (1920–2004), Holocaust survivor
Robert Messer (1887–1918), Scottish footballer
Sam Messer (21st century), American painter
Sarah Messer (born 1966), American poet and author
Thomas M. Messer (1920–2013), director of the Solomon R. Guggenheim Foundation 1961–1988
Given name:
David ben Judah Messer Leon (c. 1470 – 1526), Italian rabbi, physician and writer
Judah Messer Leon (1166), French tosafist
Judah Messer Leon (15th century), Italian rabbi, teacher, physician, and philosopher