Memapsin 1

Memapsin 1 (EC 3.4.23.45, beta-secretase, beta-site Alzheimer's amyloid precursor protein cleaving enzyme 2 (BACE2), ASP1, Down region aspartic protease) is an enzyme. This enzyme catalyses the following chemical reaction

Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein

This enzyme belongs to the peptidase family A1.