Melrose is both a surname and a given name. Notable people with the surname include:
Surname:
Barry Melrose (born 1956), former head coach of the National Hockey League's Tampa Bay Lightning & Los Angeles Kings
Charles James Melrose (1913–1936), Australian aviator and holder of early flight records between Australia and other countries
Dianna Melrose (born 1952), British diplomat, ambassador to Cuba
George Melrose (1806–1894), pioneer in South Australia
Jim Melrose (born 1958), Scottish footballer
Joseph Melrose, American diplomat who served as United States Ambassador to Sierra Leone
Richard Burt Melrose (born 1949), Australian mathematician
Robert Thomson Melrose (1862–1945), pastoralist and politician in South Australia
Given name:
Melrose Bickerstaff (born 1983), American fashion model and runner-up on America's Next Top Model, Cycle 7
Melrose Foxxx (born 1983), American pornography actress
Melrose Kai-Banya, ambassador of the Republic of Sierra Leone to the Russian Federation