Melchers is a surname of German language origin, originally found mostly in North Rhine-Westphalia (the former Prussia).
People with this surname include:
Claudia Melchers (born 1969), Dutch businesswoman and kidnapping victim
Cor Melchers (1954–2015), Dutch painter
Gari Melchers (1860–1932), American painter
Hans Melchers (born 1938), Dutch businessman
Julius Theodore Melchers (1829–1908), American sculptor
Marie Melchers (born 1939), Belgian fencer
Mirjam Melchers (born 1975), Dutch cyclist
Paul Melchers (1813–1895), German Roman Catholic clergyman
Saskia Melchers (born 1962), Dutch cricketer
The Melchers Building, the oldest commercial building in Honolulu, Hawaii, was named for one of its original occupants, trader Gustav C. Melchers.