McNicholas is a surname. Notable people with the surname include:
Conor McNicholas, British journalist and magazine editorDerek McNicholas (born 1985), Irish hurlerJohn T. McNicholas (1877–1950), Irish clergymanJoseph Alphonse McNicholas (1923–1983), American Roman Catholic bishopMaura McNicholas, Irish camogie playerPatrick McNicholas (1919–1990), Irish-born Canadian politicianPaul McNicholas (born 1975), Australian rugby league playerSteve McNicholas (born 1955), English actor and director