McNicholas is a surname. Notable people with the surname include:
Conor McNicholas, British journalist and magazine editor
Derek McNicholas (born 1985), Irish hurler
John T. McNicholas (1877–1950), Irish clergyman
Joseph Alphonse McNicholas (1923–1983), American Roman Catholic bishop
Maura McNicholas, Irish camogie player
Patrick McNicholas (1919–1990), Irish-born Canadian politician
Paul McNicholas (born 1975), Australian rugby league player
Steve McNicholas (born 1955), English actor and director
