McLane is a surname. Notable people with the surname include:
Allen McLane (1746–1829), officer in the Continental Army during the American Revolution
Ann McLane Kuster (born 1956), American lawyer and author
David McLane, Las Vegas promoter
David McLane (merchant) (ca. 1767–1797), a merchant from Providence, RI.
Derek McLane (born 1958), English born American set designer
Drayton McLane, Jr. (born 1936), American entrepreneur
Ed McLane (1881–1975), American baseball player
Eddie McLane (1899–1980), American sports coach
Harvey McLane, Canadian provincial politician
James McLane (born 1930), former United States swimmer
John McLane (1852–1911), American furniture maker and politician
Kim McLane Wardlaw (born 1954), U.S. federal judge in California
Louis McLane (1786–1857), American lawyer and politician, son of Allen McLane
Malcolm McLane (1924-2008), American lawyer, businessman, and politician
M. Jean McLane (1878–1964), American portraitist
Patrick McLane (1875–1946), American politician
Ralph McLane (1907–1951), American clarinetist
Robert Milligan McLane (1815–1898), American politician, military officer, and diplomat
S. Brooks McLane, American physicist
Susan McLane (1929-2005), American politician
Val McLane (born 1943), English actress, scriptwriter and director
William McLane (Pennsylvania), 20th century American politician
William McLane (Washington state), 19th century American politician