McGuinness, McInnis McAngus or McNeese is a Scottish and Irish name that comes from the Gaelic word Mac Angus meaning son of Angus also denoting the name Mac Naois. The family were a branch of the Ulaid, part of the Ui Echach Cobo of the Dal nAraidi, they were located in counties Antrim and Down until they pushed into northwest Ireland and Scotland during the Norman and English invasions of Ulster.
Catherine McGuinness (born 1934), Irish Supreme Court judge, former senator
Charles McGuinness (1893 – 1947), Irish adventurer, author, and sailor
Deborah McGuinness, American computer scientist working in the field of artificial intelligence
Ed McGuinness, American comic book artist and penciller
Edwin D. McGuinness, American politician, mayor of Providence, Rhode Island
Eugene McGuinness (born 1985), British singer-songwriter
Frank McGuinness (born 1953), Irish playwright, translator and poet
Georgina McGuinness (née Allen), TV journalist from Adelaide
Gerry McGuinness (born 1953), Scottish rugby union player
John J. McGuinness (born 1955), Irish Fianna Fáil politician, TD for Carlow-Kilkenny 1997—
Mairead McGuinness (born 1959), Irish Fine Gael politician, MEP 2004—
Martin McGuinness (born 1950), Irish Sinn Féin politician, MP for Mid Ulster 2001—, Deputy First Minister of Northern Ireland 2007—2017
Nathan McGuinness, visual effects supervisor
Nigel McGuinness, English professional wrestler
Norah McGuinness (1901–1980), Irish painter and illustrator
Paddy McGuinness (born 1973), English comedian
Padraic McGuinness (1938–2008), Australian journalist
Paul McGuinness, manager of Irish rock band U2
Paul "Mad Dog" McGuinness, Irish guitarist and vocalist with the band Shane MacGowan and The Popes
Seán McGuinness (died 1978), Irish Republican, TD for Leix-Offaly 1923–1925
Wilf McGuinness (born 1937), English football player and manager