McGuffin is a surname of Irish origin, thought to originate from County Donegal. It is an Anglicized form of the Gaelic Mag Dhuibhfinn. Notable people with the surname include:
David McGuffin, Canadian television correspondent
Peter McGuffin, Northern Irish geneticist
Samuel McGuffin (1863–1952), Northern Ireland politician
John McGuffin (1942–2002), political activist and author
Meg McGuffin (1993–), American beauty pageant titleholder
Gary and Joanie McGuffin, Canadian explorers, authors, and conservation photographer
