McGonigle is a surname. Notable people with the surname include:
Brendan McGonigle (1939–2007), reader in psychology at the University of Edinburgh in Scotland.
Colm McGonigle, Irish soccer player who played in the League of Ireland during the 1980s and 1990s.
Jerry McGonigle, associate professor of acting and directing at West Virginia University in Morgantown, West Virginia.
George M'Gonigle, Medical Officer for Health in Stockton-on-Tees from 1924 to 1939.