McDuffie or MacDuffie is a surname of Scottish and Irish origin. McDuffie/MacDuffie is an Anglicization of the Gaelic Mac Duibhshíthe ("son of Duibhshíth"). The Gaelic name is composed of two elements; dubh ("black") + síth ("peace"). The name is sometimes shortened to McPhee or McFee. Notable people with the surname include:
Arthur McDuffie (1946–1979) – An African American, whose death at the hands of Miami-Dade police caused one of the worst riots in United States history.
Chris McDuffie – An American musician.
Duncan McDuffie (1877–1951) – An architect, real estate developer, and conservationist in San Francisco, California, USA.
Dwayne McDuffie (1962–2011) – A comic book and animation writer.
George McDuffie (1790–1851) – A Governor of South Carolina and a member of the United States Senate.
Glenn McDuffie (1927–2014) – An American World War II sailor.
J. D. McDuffie (1938–1991) – A NASCAR Winston Cup race car driver.
James McDuffie (1929–2015) - An American politician
John McDuffie (1883–1950) – U.S. Representative from Alabama from (1919–1935).
John Van McDuffie (1841–1896) – A U.S. Representative from Alabama.
Kenyan McDuffie - Member of the Council of the District of Columbia
O. J. McDuffie (b. 1969) – A professional American football player.
Robert McDuffie – An internationally renowned violinist.
Erik McDuffie (1970-) - An American author
