McDuff (also spelled: Macduff) is a surname. It is the Anglicized form of the Scottish Gaelic name Mac Dhuibh (Mac = son, Dhuibh = dark/black). Notable people with the surname include:
Caleb McDuff, Welsh deaf racing driver
David McDuff, Scottish literary translator
Dusa McDuff, English mathematician
Daniel McDuff, Affective Computing Researcher
Jack McDuff (1926-2001), American jazz musician
Kenneth McDuff (1946-1998), American serial killer
Fictional characters:
McDuff, the Talking Dog, a children's television character
Suds McDuff, another name for The Simpsons' dog Santa's Little Helper
Father Cyril McDuff, a priest in the television series Father Ted