McCusker is a surname of Gaelic origin. Notable people with the surname include:
Aaron McCusker (born 1978), Northern Irish actor
Chris McCusker (born 1958), Australian songwriter, musician and sound designer
Damien McCusker (born 1966), Irish Gaelic footballer
Emmett McCusker (1889–1973), Canadian politician
Fergal McCusker (born 1970), Gaelic footballer
Jim McCusker (born 1936), American football defensive tackle
Joan McCusker (born 1965), Canadian curler
John McCusker (born 1973), Scottish folk musician, record producer and composer
John J. McCusker, American academic, Professor of American History and Professor of Economics
Harold McCusker (1940—1990), Northern Ireland politician
Malcolm McCusker (born 1938), Australian philanthropist and barrister, Governor of Western Australia
Marc McCusker (born 1989), Scottish footballer
Michael McCusker, American film editor
Niall McCusker (born 1980), Irish Gaelic footballer
Paul McCusker (born 1958), American writer and radio producer
Red McCusker, Canadian ice hockey goaltender
Richie McCusker (born 1970), Scottish footballer
Rob McCusker (born 1985), Welsh rugby player