|Covid-19|McCormack reaction Wikipedia
The McCormack reaction is a method for the synthesis of organophosphorus compounds. In this reaction a 1,3-diene and a source of R2P+ are combined to give phospholenium cation. The reaction is named after W. B. McCormack, a research chemist at duPont.
An illustrative reaction involves phenyldichlorophosphine and isoprene:
The reaction proceeds via an pericyclic [1+4]-process. The resulting derivatives can be hydrolyzed to give the phosphine oxide. Dehydrohalogenation gives the phosphole.